Vitamins D3 and K2, a synergistic pair
Vitamins D and K have several important properties, and this is especially relevant during a pandemic, as evidenced by research published in October 2020. This research suggests that the immunoregulatory function of vitamin D3 is promising for combating the SARS-CoV-2 coronavirus (COVID-19) and could reduce global epidemic mortality. Furthermore, the same research suggests that vitamin D3 supplementation should be accompanied by vitamin K2 intake. Many nutrition experts consider these vitamins synergistic, meaning they work together to enhance each other's beneficial effects. Vitamin K2 helps vitamin D3 exert its effects while preventing the adverse effects associated with excessive supplementation. Working together, these two vitamins strengthen bones and improve heart health.
For an active life, it's very important that our bones and muscles are strong. As we age, the balance between bone breakdown and regeneration becomes unbalanced, leading to bone loss; in other words, bones gradually lose density. Hormones, diet, and medications affect bone metabolism and can further accelerate this deterioration. An active lifestyle with plenty of movement is beneficial for bone and muscle health at any age. Furthermore, our musculoskeletal system needs a number of micronutrients, especially vitamin D, vitamin K2, and calcium.
Vitamin D is an essential nutrient for the healthy development and maintenance of teeth and bones. This vitamin helps the body absorb calcium, which, along with phosphorus, is necessary for normal bone formation. In childhood, the body uses these minerals to build bone. If there is not enough calcium, or if the body does not absorb enough calcium from the diet, bone production and bone tissue can be impaired. Vitamin D deficiency can lead to osteoporosis in adults or rickets in children.
The vitamin D molecule is fat-soluble, meaning it dissolves in fats, and although there are up to five types of vitamin D, the human body can only recognize two of them: vitamin D2, or ergocalciferol, and vitamin D3, or cholecalciferol. The latter is more potent than ergocalciferol.
Vitamin D2 can be found in plant-based foods and some mushrooms, while consuming animal products such as oily fish, eggs, and dairy products will increase vitamin D3 levels. Sun exposure can also promote the production of cholecalciferol, which is why D3 is known as the sunshine vitamin.
Both cholecalciferol and ergocalciferol are inactive forms of vitamin D. Before they can exert their beneficial effects, both substances must be metabolized by the liver and kidneys to produce the active form of this vitamin: calcitriol. Therefore, what differentiates D3 and D2 is their origin. However, numerous studies have shown that vitamin D3 produces a greater conversion to calcitriol compared to its counterpart. For this reason, cholecalciferol is the preferred form of vitamin D among most nutrition experts.
The primary role of vitamin D in maintaining calcium and phosphorus homeostasis, whether through increased intestinal calcium absorption or its activity in bone metabolism, is well-established. However, vitamin D also exerts effects on the immune system, the microendocrine system of the vasculature, and in reducing the risk of developing various types of cancer. Its effects on the cardiovascular system are supported by studies suggesting that vitamin D intake helps prevent conditions such as atherosclerosis, hypertension, insulin resistance, and hyperglycemia; essential risk factors in the development of metabolic syndrome, which combines a series of genetic and lifestyle factors that increase predisposition to cardiovascular events. These include hyperglycemia, hypertension, dyslipidemia, and abdominal obesity, all of which may be related, directly or indirectly, to vitamin D deficiency.
It could be said that among the functions of vitamin D3 are: acting as an immunoregulator to fight viruses, preventing the risk of developing different types of cancer, increasing intestinal calcium absorption, controlling phosphorus and calcium levels in the kidney, contributing to the formation and renewal of bone tissue and dental strengthening, helping muscle contraction, protecting neuronal tissue against aging, and minimizing risk factors for the appearance of metabolic syndrome.
Like vitamin D, vitamin K is also a fat-soluble substance whose absorption is enhanced when ingested in the presence of fats. It was named vitamin K for its clotting effect (in German, Koagulation ), and although there are five variants of this vitamin, its two natural derivatives are vitamin K1, or phylloquinone, abundant in green leafy vegetables, and vitamin K2, or menaquinone, present in foods of animal origin and fermented soy products.
Although both forms of vitamin K are essential for activating proteins that regulate blood clotting and other equally important metabolic processes, vitamin K2 is associated with a decrease in calcium deposits in blood vessels, improving vascular health, while vitamin K1 lacks this property. It has been observed that older adults, especially women, who maintain high levels of vitamin K2 benefit from a lower incidence of osteoporosis and arterial calcification, something that does not occur among those who consume only K1. This is the main difference between the two molecules.
Vitamin K, in any of its forms, acts as a cofactor, or molecule involved in blood clotting. It also functions as a metabolic regulator and antioxidant, offering protection and helping to reduce the risk of developing various types of cancer, including liver, leukemia, lung, colon, oral, breast, and gallbladder cancers. Furthermore, it is necessary for activating extracellular matrix proteins in bone and smooth muscle cells, which enable calcium binding, thus regulating bone metabolism and reducing the risk of cardiovascular disease by helping to prevent arterial and cardiac calcifications.
Vitamin D3 deficiency can cause insidious effects, generating a nonspecific feeling of fatigue and malaise. If this situation is not corrected, problems will arise in the metabolism of calcium and other minerals, leading to osteoporosis, joint pain, and bone and muscle injuries. Problems stemming from vitamin K2 deficiency will primarily affect the body's ability to clot. Even the slightest friction will result in bruising, wounds, or bleeding (for example, bleeding gums after brushing teeth). In women, menstrual periods will become very heavy and take longer to cease.
Some vitamin D3 and K2 supplements incorporate calcium into their formulas to help increase bone support. Additionally, they include Bioperine®, a patented product containing 95% piperine extracted from black pepper ( Piper Nigrum L.), which activates thermogenesis, the mechanism that promotes digestive processes and also helps with better and faster calcium absorption in the bones.
Vitamin D3 and K2 supplements have been suggested for individuals in the following groups: those over 60 years of age, vegans or strict vegetarians, individuals with limited sun exposure, postmenopausal women, especially those with bone loss, obese individuals or those who have undergone bariatric surgery or any type of bowel resection, people with cardiovascular problems such as hypertension or heart failure, people following very restrictive or unbalanced diets, and people with kidney failure. The combination of vitamins D3 and K2 may be particularly beneficial for those with a family or personal history of cardiac events associated with arterial calcium deposits. In this case, vitamin K2 would act as a protective element, preventing the arterial calcium deposits that can be caused by D3 supplementation.
If you already understand the science behind this crucial synergy, the next step is ensuring you get both vitamins in their most effective forms. Our Efika Health Advanced Vitamin K2 with D3 Formula is designed precisely for this purpose. We combine the optimal dose of Vitamin D3 (essential for absorption) with the superior form of Vitamin K2 ( MK-7 )—the key cofactor that ensures absorbed calcium is efficiently directed to strengthen your bones and teeth, while maintaining the health and flexibility of your arteries. Don't leave your bone and cardiovascular health to chance; choose the advanced formulation that respects science.Get your synergistic support today and feel the difference of superior calcium absorption and utilization!
Ramona Ávila Núñez, Ph.D.
REFERENCES
- MedlinePlus. Health information for you. Available at https://medlineplus.gov/spanish/ency/article/002405.htm
- Goddek, S. Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate. International Journal of Infectious Diseases 2020; 99:286-90
- Rajakumar K. Vitamin D. Codliver oil, sunlight, and rickets: a historical perspective. Pediatrics 2003; 112: 132-5.
- Pozzo, M. Vitamin D: Non-classical actions. Updates in osteology 2005; 1: 28-33.
- Moon J, Bandy B, Davison A. Hypothesis: etiology of atherosclerosis and osteoporosis: are imbalances in the calciferol endocrine system involved? J Am Coll Nutr 1992; 11: 567-83.
- Pfeifer M, Begerow B, Minne H, Nachtigall D, Hansen C. Effects of a short-term Vitamin D 3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women . J Clin Endocrinol Metab 2001; 86: 1633-7.
- Chiu K, Chu A, Go V, Saad M. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004; 79: 820-5.
- Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey. Diabetes care 2004; 27: 2813-8.
- Querales I, Cruces M, Rojas S, Sánchez L. Vitamin D deficiency: A risk factor for metabolic syndrome? Revista Médica de Chile 2010; 138 (10), 1312-8. Available from: https://dx.doi.org/10.4067/S0034-98872010001100017
- Van Ballegooijen, A.J.; Beulens, JW 2017. The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies. Current Nutrition Reports 6 (3): 197-205.
- Barrett, H, O'Keeffe, M. Kavanagh, Eamon; Walsh, Michael; O'Connor, Eibhlís M. 2018. Is Matrix Gla Protein Associated with Vascular Calcification? A Systematic Review. Nutrients (Multidisciplinary Digital Publishing Institute (MDPI)) 10 (4): 415.
- Dasari, Subramanyam; Ali, Syed M.; Zheng, Guoxing; Chen, Aoshuang; Dontaraju, Venkata Satish; Bosland, Maarten C. 2017. Vitamin K and its analogs: Potential avenues for prostate cancer management Oncotarget (Impact Journals, LLC ) 8 (34): 57782-57799.