Is it possible to prevent diabetes in children by improving their gut flora?
Recent research on the gut microbiota has found that it is very feasible to prevent future autoimmune diseases, such as diabetes, in newborns by improving their gut flora.
Although much remains to be discovered, there is ample evidence of the far-reaching effects of the gut microbiome on the overall functioning of the body. This is why many researchers have dedicated themselves to studying its potential effects from the very beginning of the microbiome's formation in newborns.
A difference has been observed between the gut microbiota of babies born vaginally and those born by cesarean section, due to their exposure to the mother's microbiota during passage through the vagina. Furthermore, alterations in the gut microbiota of babies born by cesarean section have been demonstrated, caused by the use of antibiotics. Accordingly, it is considered that there is a higher risk of future autoimmune diseases in children born by cesarean section.
A study conducted on mice observed that early antibiotic use alters the gut microbiota and can lead to the development of type 1 diabetes. However, studies have shown that restoring the gut microbiome through maternal microbiota transfer can largely prevent the development of this disease. This treatment had a significant and lasting effect, demonstrating its effectiveness in preventing the development of this disease.
Maintaining a healthy gut microbiota from the beginning of our lives is essential to ensure a healthy life with all the benefits it offers.
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References
- Zhang, Xue-Song et al. Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice. Cell Host & Microbe , July 20 2021
- https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00296-1
- Katri Korpela, Otto Helve, Kaija-Leena Kolho, Terhi Saisto, Kirsi Skogberg, Evgenia Dikareva, Vedran Stefanovic, Anne Salonen, Sture Andersson, Willem M. de Vos. Maternal fecal microbiota transplantation in infants born by cesarean section rapidly restores normal gut microbial development: a proof-of-concept study. Cell , 2020; DOI: 10.1016/j.cell.2020.08.047